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1H‐Indole Derivatives as Calcium Antagonists
Author(s) -
Garuti Laura,
Giovanninetti Giuseppe,
Bova Sergio,
Chiarini Alberto
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210702
Subject(s) - indole test , guinea pig , chemistry , piperazine , calcium , inotrope , stereochemistry , hydantoin , smooth muscle , pharmacology , biochemistry , endocrinology , biology , organic chemistry
Two short series of compounds with 1H‐indole skeleton, bearing hydantoin and piperazine nuclei respectively, were synthesized. Some compounds of these two series were tested for their calcium‐antagonistic activity on K + ‐depolarized smooth muscle (rabbit auricolar artery and guinea‐pig taenia caeci) and their negative inotropic action on atrial muscle from guinea‐pig hearts.