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Mass Spectrometric Investigations of Phenylacetic Acid Derivatives, III: Fragmentations of meta‐ and para‐substituted Phenylacetamides after Electron Impact
Author(s) -
Lee DongUng,
Mayer Klaus K.,
Wiegrebe Wolfgang
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210603
Subject(s) - chemistry , electron ionization , fragmentation (computing) , phenylacetic acid , yield (engineering) , ion , medicinal chemistry , mass spectrum , cleavage (geology) , mass spectrometry , stereochemistry , organic chemistry , chromatography , geotechnical engineering , fracture (geology) , engineering , metallurgy , ionization , operating system , materials science , computer science
The electron impact induced fragmentations of m‐ and p‐substituted phenylacetamides and N,N‐dimethyl‐phenylacetamides 1 – 14 were investigated and compared with the o‐analogues. All m‐ and p‐substituted amides yield molecular ions with high relative intensities which do not lose their meta‐ and para‐substituents. Loss of HNCO from M + ˙ is dominant in the prim, amides, whilst for the tert. amides the classical benzyl cleavage is the most favourable fragmentation pathway.