Premium
Chemical properties‐dissolution relationship of NSAIDs. III. Release from Monoliths in a Three Phase System
Author(s) -
Fini Adamo,
Orienti Isabella,
Zecchi Vittorio
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210407
Subject(s) - dissolution , ketoprofen , solubility , chemistry , phase (matter) , inert , partition coefficient , chemical engineering , chromatography , aqueous solution , organic chemistry , engineering
The three phase dissolution‐partition process of Fenbufen and Ketoprofen from inert matrices (monoliths), obtained by direct compression in presence of polymeric excipients, has been studied at different pH of the dissolution medium. The presence of both a lipidic phase and an oil saturated aqueous extracting phase, significantly increases the release rate of the active principles from these devices; the solubility of the drugs appears to play a major role in the whole process which is also affected by the different affinity of the drugs towards the supporting material.