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Enzymatic Synthesis of ( S ‐(−)‐3‐(3,4‐Dihydroxyphenyl)lactic Acid
Author(s) -
Rao Nagaraj N.,
Roth Hermann J.
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210315
Subject(s) - lactic acid , metabolite , enzyme , chemistry , biochemistry , stereochemistry , bacteria , biology , genetics
The first enzymatic synthesis of ( S )‐(−)‐3‐(3,4‐dihydroxyphenyl)lactic acid, a DOPA metabolite and naturally occurring compound with a broad spectrum of pharmacological activities, is described. L‐Hydroxyisocaproate dehydrogenase was used as enzyme.