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Synthesis and Cytostatic Screening of an SO 2 Analogue of Doridosine
Author(s) -
Goya Pilar,
Martínez Ana
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210213
Subject(s) - hela , chemistry , cleavage (geology) , stereochemistry , glycosidic bond , ring (chemistry) , combinatorial chemistry , bicyclic molecule , organic chemistry , cell , biochemistry , biology , fracture (geology) , enzyme , paleontology
Imidazo[4,5‐ c ][1,2,6]thiadiazine ribosides have been prepared from furazano[3,4‐ c ][1,2,6]thiadiazine 5,5‐dioxides in a reaction sequence which involves introduction of the glycosidic rest, reductive cleavage of the furazan ring and cyclization. The ribosides were screened against HeLa cell cultures but showed no significant activity.