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Potential Histamine H 2 ‐Receptor Antagonists: Analogues of Classical Antagonists Containing 4‐Substituted‐3‐Aminofurazan Moieties
Author(s) -
Defilippi Albino,
Sorba Giovanni,
Calvino Rosella,
Garrone Adele,
Gasco Alberto,
Orsetti Marco
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210207
Subject(s) - moiety , chemistry , stereochemistry , in vitro , histamine , receptor , bicyclic molecule , biochemistry , pharmacology , biology
Analogues of classical H 2 ‐receptor antagonists containing aminofurazan moieties as polar groups were synthesized and tested “in vitro” for their activities. Compounds containing 3‐amino‐4‐methylfurazan and 4‐amino‐3‐methylfuroxan substructures show good antagonistic properties. The compound containing the 3‐amino‐4‐phenylfurazan moiety is inactive. An SAR approach is discussed.