α‐Halo ketoximes in Heterocyclic Synthesis: Polyfunctional Azoles and Azines from α‐Bromo ketoximes | Zendy

Mohareb R. M. | Zendy; Habashi A. | Zendy; Hafez E. A. A. | Zendy; Sherif S. M. | Zendy

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α‐Halo ketoximes in Heterocyclic Synthesis: Polyfunctional Azoles and Azines from α‐Bromo ketoximes

Author(s) -

Mohareb R. M.,

Habashi A.,

Hafez E. A. A.,

Sherif S. M.

Publication year - 1987

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19873200903

Subject(s) - chemistry , malononitrile , oxime , thiourea , thiocyanate , cyanide , halogen , azole , medicinal chemistry , organic chemistry , ethyl cyanoacetate , combinatorial chemistry , antifungal , catalysis , medicine , dermatology , alkyl

α‐Bromoacetophenone oxime (2) undergoes halogen substitutions with cyanide and thiocyanate ions to give 4 and 6 , respectively. The oxime 2 also reacts with thiourea to give the thiadiazine 12 , with malononitrile and ethyl cyanoacetate to give the pyrido[3,2‐ e ]oxazine 13 and the oxazine 14 , respectively. With hydrazines 2 reacts to give the triazoles 15a, b .

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