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Analyses of Drugs by Polarographic Methods, XXX: Electrochemical Behaviour of Metaclazepam
Author(s) -
Oelschläger Herbert,
Ellaithy Moustafa M.
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200808
Subject(s) - polarography , chemistry , electrolysis , electrochemistry , diffusion , chromatography , analytical chemistry (journal) , inorganic chemistry , thermodynamics , electrode , electrolyte , physics
The electrochemical behaviour of the new anxiolytic drug metaclazepam (1) is studied. In buffers containing 10 % DMF, the compound is polarographically active over the entire pH range with a single well‐defined wave. This wave has been characterised as being 2e‐diffusion‐controlled. The dihydro derivative 2 was synthesised by controlled potential electrolysis (c.p.e.). At more negative potentials a second wave appears in neutral and alkaline buffers. ‐ The main reduction step can be used for the quantitative analysis (DPP) of 1 down to 5 · 10 −7 M and in its tablets of 5 or 10 mg (content uniformity test USP XXI). Standard deviations are ± 1.24 % and ± 0.95 %, respectively.