z-logo
Premium
Ether Derivatives of 3‐Amino‐1,2‐propanediols, VI Syntheses and Pharmacological Investigations of 5,8‐Bis[2‐hydroxy‐3‐(alkylamino)propoxy]‐1,4‐dihydronaphthalenes
Author(s) -
Chalina Elena,
Christova Krastina,
Dantchev Damian,
Staneva Duska,
Rainova Lilyana,
Chakarova Lidia
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200716
Subject(s) - aminolysis , chemistry , ether , biological activity , chemical synthesis , stereochemistry , organic chemistry , catalysis , biochemistry , in vitro
By reaction of 5,8‐dihydroxy‐1,4‐dihydronaphthalene ( 1 ) with epichlorohydrine 5,8‐bis‐(2,3‐epoxypropoxy)‐1,4‐dihydronaphthalene ( 2 ) was synthesized. Aminolysis of 2 led to the 3‐amino‐1,2‐propanediols 3‐13 . Pharmacological screening showed hypotensive and β‐adrenoceptor blocking activities, as well as low toxicity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here