Premium
Ether Derivatives of 3‐Amino‐1,2‐propanediols, VI Syntheses and Pharmacological Investigations of 5,8‐Bis[2‐hydroxy‐3‐(alkylamino)propoxy]‐1,4‐dihydronaphthalenes
Author(s) -
Chalina Elena,
Christova Krastina,
Dantchev Damian,
Staneva Duska,
Rainova Lilyana,
Chakarova Lidia
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200716
Subject(s) - aminolysis , chemistry , ether , biological activity , chemical synthesis , stereochemistry , organic chemistry , catalysis , biochemistry , in vitro
By reaction of 5,8‐dihydroxy‐1,4‐dihydronaphthalene ( 1 ) with epichlorohydrine 5,8‐bis‐(2,3‐epoxypropoxy)‐1,4‐dihydronaphthalene ( 2 ) was synthesized. Aminolysis of 2 led to the 3‐amino‐1,2‐propanediols 3‐13 . Pharmacological screening showed hypotensive and β‐adrenoceptor blocking activities, as well as low toxicity.