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Derivatives of 2‐Amino‐1,2,3,4‐tetrahydronaphthalene XI 1 ): trans ‐6,9‐Dimethoxy‐2,3,4a,5,10,10a‐hexahydro‐4 H ‐naphth[2,3‐ b ]1,4‐oxazines ‐ Tricyclic Analogs of trans ‐2‐Amino‐3‐hydroxy‐5,8‐dimethoxytetralins
Author(s) -
Troanska G.,
Christova K.,
Danchev D.
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200711
Subject(s) - chemistry , stereochemistry , medicinal chemistry
Abstract Cyclization of chloroacetyl derivatives of the aminotetraloles 2 and 3 in alcoholic KOH yields 3‐oxonaphthalane‐morpholines. Their reduction with LiAlH 4 gave the naphthalane‐morpholines 5 . The pharmacological screening of 5a ′ showed central stimulative, peripheral adrenergic, and analgetic activities.