Premium
Polyfunctionally Substituted Pyridines from Cyanoacetamide and Cyanoacetanilide
Author(s) -
Mohareb R. M.,
Habashi A.,
Shams H. Z.,
Fahmy S. M.
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200706
Subject(s) - cyanoacetamide , chemistry , electrophile , reagent , yield (engineering) , combinatorial chemistry , organic chemistry , catalysis , materials science , metallurgy
The polyfunctionally substituted pyridines 3a, b obtained from cyanoacetamide and cyanoacetanilide are reactive reagents. They cyclize under acidic and basic conditions and react with electrophiles to yield a variety of compounds (Scheme 2).