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Synthesis and Biological Activity of 2‐Adamantanone Oxime Carbamate Derivatives
Author(s) -
Georgiev Vassil St.,
Bennett Grace A.,
Radov Lesley A.,
Kamp Dietgard K.,
Trusso Laura A.
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200516
Subject(s) - chemistry , oxime , carbamate , in vitro , biological activity , antifungal , stereochemistry , yeast , carrageenan , organic chemistry , pharmacology , biochemistry , microbiology and biotechnology , biology
The synthesis of a number of new 2‐adamantanone oxime carbamate derivatives (7a‐h) is described. When tested in the carrageenin‐induced rat paw edema assay, some of the compounds exerted moderate anti‐inflammatory activity. In addition, the title 2‐adamantanone oxime carbamates showed in vitro antifungal activity against yeast and systemic mycoses and dermatophytes.