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Pharmacokinetics of Atenolol and Metoprolol Administered together with Piroxicam
Author(s) -
Spahn Hildegard,
Langguth Peter,
Krauss Dorit,
Kirch Wilhelm,
Mutschler Ernst
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200203
Subject(s) - atenolol , metoprolol , pharmacokinetics , piroxicam , pharmacology , chemistry , plasma concentration , medicine , blood pressure , alternative medicine , pathology
A possible pharmacokinetic interaction of atenolol or metoprolol and piroxicam was investigated over a period of 7 days. The mean plasma concentration versus time curve of atenolol (n=6) was nearly uninfluenced, whereas the mean metoprolol concentrations (n=6) were enhanced (statistically not significant). The pharmacokinetic parameters of both atenolol and metoprolol obtained from the plasma concentrations and urinary excretion on the 7. day of treatment were not significantly changed.