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Analyses of Drugs by Polarographic Methods, XXVII The Polarographic Behaviour of Uldazepam
Author(s) -
Oelschläger Herbert,
Ellaithy Moustafa M.
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19873200113
Subject(s) - polarography , tranquilizer , chemistry , diffusion , stereochemistry , chromatography , inorganic chemistry , pharmacology , thermodynamics , medicine , physics
Uldazepam ( 1 ), a tranquilizer belonging to the 1.4‐benzodiazepine group is reduced at the DME through two reduction steps in acid media. The first is an irreversible diffusion‐controlled step due to the uptake of 2e by the —N=CR‐double bond of 1 , the second one being an irreversible diffusion‐controlled 4e‐step. The mechanism is under investigation. A DPP method is presented for the determination of 1 at concentration as low as 5 · 10 −8 M.