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Studies on the Synthesis of some Flavonoid Derivatives Possessing Spasmolytic Activity
Author(s) -
Ertan Mevlüt,
Ertan Rahmiye,
Göker Hakan,
Pindur Ulf
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.198700021
Subject(s) - chemistry , histamine , flavonoid , acetylcholine , stereochemistry , biological activity , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , pharmacology , biochemistry , in vitro , biology , antioxidant
3′,4′‐Dihydroxyflavone reacts with ethyl 2,3‐dibromopropanoate to form the new, substituted 1,4‐benzodioxanes 1 . The regioisomers 1a and 1b were separated by crystallization and converted to the amides 2a and 2b for pharmacological testing for spasmolytic activity. The constitutions of 1 and 2 were elucidated by 400 MHz 1 H‐NMR spectroscopy. In the spasmolysis test, antagonistic effects towards acetylcholine, BaCl 2 and histamine were investigated. Non‐specific spasmolytic activities were detected.