Studies on the Synthesis of some Flavonoid Derivatives Possessing Spasmolytic Activity | Zendy

Ertan Mevlüt | Zendy; Ertan Rahmiye | Zendy; Göker Hakan | Zendy; Pindur Ulf | Zendy

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Studies on the Synthesis of some Flavonoid Derivatives Possessing Spasmolytic Activity

Author(s) -

Ertan Mevlüt,

Ertan Rahmiye,

Göker Hakan,

Pindur Ulf

Publication year - 1987

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.198700021

Subject(s) - chemistry , histamine , flavonoid , acetylcholine , stereochemistry , biological activity , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , pharmacology , biochemistry , in vitro , biology , antioxidant

3′,4′‐Dihydroxyflavone reacts with ethyl 2,3‐dibromopropanoate to form the new, substituted 1,4‐benzodioxanes 1 . The regioisomers 1a and 1b were separated by crystallization and converted to the amides 2a and 2b for pharmacological testing for spasmolytic activity. The constitutions of 1 and 2 were elucidated by 400 MHz 1 H‐NMR spectroscopy. In the spasmolysis test, antagonistic effects towards acetylcholine, BaCl 2 and histamine were investigated. Non‐specific spasmolytic activities were detected.

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