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Syntheses of 3,6‐Substituted‐4‐(3′,4′,5′‐Substituted‐1′‐pyrazolyl)‐isoxazolo[5,4‐ d ]pyrimidines as Potential Antiinflammatory Agents
Author(s) -
Adhikari Vasudeva A.,
Badiger Virupax V.
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.198700020
Subject(s) - chemistry , antifungal , combinatorial chemistry , stereochemistry , antibacterial activity , bacteria , chemical synthesis , analgesic , pathogenic bacteria , pharmacology , in vitro , microbiology and biotechnology , biochemistry , biology , genetics
Twentyseven title compounds were synthesized from (un)substituted benzaldehydes. Their antibacterial and antifungal activities against four pathogenic bacteria and three fungi were investigated. Nine compounds were tested for antiinflammatory and analgesic activities by standard methods. A few of the compounds gave promising results.