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Synthesis and Calcium‐antagonist Activity of some Phosphonates
Author(s) -
Corsano Stefano,
Strappaghetti Giovannella,
Castagnino Enzo
Publication year - 1987
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.198700019
Subject(s) - antagonist , chemistry , calcium , biological activity , chemical synthesis , pharmacology , stereochemistry , biochemistry , in vitro , receptor , organic chemistry , biology
The synthesis and pharmacological evaluation of a series of phosphonates related to Fostedil, diethyl 4‐(benzothiazol‐2‐yl)benzylphosphonate 1 , a potent calcium antogonist are reported. Among the compounds studied, only diethyl 4‐(benzooxazol‐2‐yl)benzylphosphonate 5 , which is closely related to Fostedil, shows a low calcium‐antagonist activity.
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