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Dithranol and active oxygen species, II. 1 O 2 ‐oxidation of dithranol to Chrysazin
Author(s) -
Müller Klaus,
Mayer Klaus K.,
Wiegrebe Wolfgang
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863191109
Subject(s) - dithranol , chemistry , photosensitizer , stereochemistry , oxygen , rose bengal , photochemistry , organic chemistry , biology , immunology , psoriasis
Raab 's biochemically active species, derived from dithranol ( 1 ), is the anion 1a (Sect. A), which is a photosensitizer. Its sensitizing potency is quantitatively compared with that of rose bengal, tetraphenylporphyrine and other sensitizers (Sect. B). In Sect. C the mechanism of the conversion of 1a with 1 Δg 18 O 2 to chrysazin ( 2 ) is elucidated.