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Studies on Histaminergic Compounds, III. Synthesis and Histamine H 2 ‐Activity of a Series of Corresponding Histamine and Dimaprit Analogues
Author(s) -
Sterk G. J.,
Van Goot H. Der,
Timmerman H.
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863190710
Subject(s) - dimaprit , histaminergic , histamine , chemistry , histamine h2 receptor , stereochemistry , series (stratigraphy) , histamine receptor , histamine h3 receptor , receptor , pharmacology , biochemistry , antagonist , biology , paleontology
Structure‐activity relationships of a series of histamine analogues were found to be identical, except for one minor discrepancy, to those of a series of corresponding dimaprit analogues. It was concluded that histamine and dimaprit most probably interact with the same binding sites of the histamine H 2 ‐receptor.

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