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Ether Derivatives of 3‐Amino‐1,2‐propanediols, V. Syntheses and Pharmacological Activities of 5‐(Cycloalkoxymethyl)oxazolidines and N –Substituted Derivatives
Author(s) -
Chalina Elena,
Dantchev Damian,
Georgiev Atanas,
Mitova Kamelia
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863190706
Subject(s) - chemistry , ether , formaldehyde , biological activity , chemical synthesis , stereochemistry , organic chemistry , biochemistry , in vitro
The 5‐(cycloalkoxymethyl)oxazolidines 5a, b and their N ‐substituted derivatives 3a–j were synthesized by reaction of the aminopropanols 4a, b and 2a–j with formaldehyde. Some of the compounds were found to have moderate β‐blocking activity and 3b and 3h were found to have considerable antiarrhythmic activity.