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Stereospecificity of the Photoinduced Conversion of Methylphenobarbital to Mephenytoin
Author(s) -
Bartoń Henryk J.,
Bojarski Jacek,
Żurowska Aleksandra
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863190514
Subject(s) - stereospecificity , chemistry , ion , mephenytoin , stereochemistry , organic chemistry , catalysis , enzyme , cytochrome p450 , cyp2c19
Photochemically, an anion of S (+)‐5‐ethyl‐1‐methyl‐5‐phenylbarbituric acid is converted stereospecifically to R (‐)‐5‐ethyl‐3‐methyl‐5‐phenylhydantoin at room temperature. The R configuration is proposed for (‐)‐5‐allyl‐3‐methyl‐5‐phenylhydantoin.
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