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The Crystal and Molecular Structures of N 4 ‐(5‐Bromosalicylidene)‐ N 1 ‐(3,4‐dimethyl‐5‐isoxazolyl)sulfanilamide
Author(s) -
Hämäläinen Reijo,
Lehtinen Maire,
Turpeinen Urho
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863190507
Subject(s) - salicylaldehyde , sulfanilamide , chemistry , crystal structure , molecule , schiff base , stereochemistry , antimicrobial , base (topology) , chemical structure , nitrile , medicinal chemistry , crystallography , organic chemistry , biochemistry , mathematical analysis , mathematics
The structure of the title compound was determined by X‐ray analysis. Medicinal compounds with Schiff base structure have been widely synthesized and investigated in recent years. The functional group‐CHN‐ of the Schiffbases has been shown to have considerable biological importance 1) . Many compounds with such a structure have important analgesic, anti‐inflammatory, antibiotic, antimicrobial and especially anticancer activities 2‐8) . Medicinal sulphonamides, having a primary amino group in their molecule, react very easily with salicylaldehyde or its derivatives 9) . Information about the exact structure of the reaction products is rather scanty, however, even though the formation reaction of the base has been utilized in many analytical procedures for medicinal sulphonamides 9‐12) and many such Schiff bases have been found to possess good bacteriostatic properties 13‐14) .