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Pharmacological Studies of Two Novel Polycyclic Derivatives of Ephedrine
Author(s) -
van Der Schyf Cornelis J.,
Dekker Theodor G.,
Snyckers Friedrich O.
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863190506
Subject(s) - ephedrine , chemistry , analgesic , pharmacology , mechanism of action , acetic acid , in vitro , biochemistry , medicine
The syntheses and pharmacological evaluation of two polycyclic ephedrine derivatives 5 and 6 , are reported. Using the acetic acid induced writhing test and the carrageenin induced rat‐paw oedema test, the compounds were found to have analgesic and anti‐inflammatory properties. Further investigation of the anti‐inflammatory effect of 5 in adrenalectomised rats showed an indirect mechanism of action.