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New Acylated 1,2,4‐Triazoles as Antiviral Agents
Author(s) -
Somorai Tarmás,
Szilágyi Géza,
Reiter József,
Pongó László,
Láng Tibor,
Toldy Lajos,
Horváth Stephen
Publication year - 1986
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19863190309
Subject(s) - chemistry , stereochemistry , virus , structure–activity relationship , viral replication , cell culture , combinatorial chemistry , virology , biology , biochemistry , in vitro , genetics
The syntheses and antiviral properties of the new acylated 1,2,4‐triazole derivatives 4 are described. In cell culture experiments 6 out of 99 compounds specifically inhibit rubella virus replication to a high degree. Structure‐activity relationships are discussed.
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