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Cardiotonic Activity of 2,5‐Dimethoxyphenylimidazo[2,1‐ b ]‐thiazoles
Author(s) -
Andreani Aldo,
Rambaldi Mirella,
Bonazzi Daniela,
Bossa Rosaria,
Galatulas Iraklis
Publication year - 1985
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19853181109
Subject(s) - inotrope , contractility , chemistry , biological activity , guinea pig , pharmacology , stereochemistry , medicine , biochemistry , in vitro
We report about the synthesis and the activities of imidazo[2,1‐ b ]thiazoles and ‐thiazolines bearing a 2,5‐dimethoxyphenylgroup at position 6. The inotropic activity was investigated in isolated guinea pig atria. Compound 10 shows a strong positive inotropic activity: it increases the myocardial contractility in normal and hypodynamic heart muscle.