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Investigations in the Thiazolidine Series
Author(s) -
Hamri Abdesselam,
Péra MarieHélèna,
Valenti Rosario,
Boucherle André
Publication year - 1985
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19853180808
Subject(s) - thiazolidine , chemistry , antimicrobial , stereochemistry , biological activity , agonist , proton nmr , organic chemistry , biochemistry , in vitro , receptor
Several spirothiazolidines and N ‐acyl derivatives of ethyl thiazolidine‐4‐carboxylate have been synthetised. IR and NMR spectra have been studied. Pharmacological studies show GABA agonist activity for one of the spirothiazolidines and weak antimicrobial activity for two of them. No activity was apparent in a leukemia screen test.