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Hydroxy‐3‐(hydroxyphenyl)indoles. Relationship between structure and estrogen receptor affinity
Author(s) -
Strohmeier Josef,
Angerer Erwin Von
Publication year - 1985
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19853180508
Subject(s) - indole test , affinities , chemistry , stereochemistry , estrogen receptor , estrogen , binding affinities , receptor , chemical synthesis , biochemistry , in vitro , biology , endocrinology , medicine , cancer , breast cancer
Syntheses and estrogen receptor affinities of the 1,2‐dialkyl(hydroxy)‐3‐(hydroxyphenyl)indoles 11b–19b are described. Derivatives 15b, 16b with a hydroxy group at position 6 of the indole and an ethyl group at C‐2 show a strong binding affinity with an RBA value of 0.72 (estradiol = 100).
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