Sulfonamides Acting on the Central Nervous System, VI | Zendy

Monzani Agar | Zendy; Gamberini Gianfranco | Zendy; Braghiroli Daniela | Zendy; Bella Maria Di | Zendy; Raffa Lina | Zendy; Sandrini Maurizio | Zendy

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Sulfonamides Acting on the Central Nervous System, VI

Author(s) -

Monzani Agar,

Gamberini Gianfranco,

Braghiroli Daniela,

Bella Maria Di,

Raffa Lina,

Sandrini Maurizio

Publication year - 1985

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19853180404

Subject(s) - convulsant , chemistry , central nervous system , stereochemistry , series (stratigraphy) , shock (circulatory) , neuroscience , receptor , biochemistry , biology , medicine , paleontology

A series of 2‐(acylamino)benzenesulfonamides was prepared. Their anti‐convulsant effects on two convulsives (electro‐shock and pentetrazol) were studied. The structure/effect relationships were compared with those of a series of isomeric 2‐aminobenzenesulfon‐N‐acylamides and of 2‐nitrobenzenesulfon‐N‐acylamides. The possible influence of pK a and log P was examined.

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