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Sulfonamides Acting on the Central Nervous System, VI
Author(s) -
Monzani Agar,
Gamberini Gianfranco,
Braghiroli Daniela,
Bella Maria Di,
Raffa Lina,
Sandrini Maurizio
Publication year - 1985
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19853180404
Subject(s) - convulsant , chemistry , central nervous system , stereochemistry , series (stratigraphy) , shock (circulatory) , neuroscience , receptor , biochemistry , biology , medicine , paleontology
A series of 2‐(acylamino)benzenesulfonamides was prepared. Their anti‐convulsant effects on two convulsives (electro‐shock and pentetrazol) were studied. The structure/effect relationships were compared with those of a series of isomeric 2‐aminobenzenesulfon‐N‐acylamides and of 2‐nitrobenzenesulfon‐N‐acylamides. The possible influence of pK a and log P was examined.