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Studies on Potential Antiviral Compounds, XXIII. 2‐(Substituted benzoylamino)‐3,5‐dichloropyridines and isosteric benzamides
Author(s) -
Ferranti Anna,
Garuti Laura,
Giovanninetti Giuseppe,
Borgatti Mariangela,
Bartoletti Anna Maria
Publication year - 1985
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19853180114
Subject(s) - moiety , chemistry , stereochemistry , herpes simplex virus , in vitro , strain (injury) , medicinal chemistry , virus , virology , biochemistry , biology , anatomy
Novel 2‐(substituted benzoylamino)‐3,5‐dichloropyridines and isosteric benzamides were synthesized and tested in vitro against the MP strain of herpes simplex virus type 1 [HSV‐1(MP)]. The introduction of methoxy groups at the 2‐ and 6‐positions of the benzoyl moiety yielded compounds which significantly inhibit HSV‐1(MP) growth. Substitution with fluorine at the 4‐position of the benzoyl group resulted in inactive compounds and on the whole led to enhanced cell toxicity. 2‐(3‐Bromo‐2,6‐dimethoxybenzoylamino)‐3,5‐dichloropyridine ( 11 ) was the most active compound (2.06 log 10 units > 99% inhibition at 100μg/ml).