Synthesis of Substituted 3‐Hydroxy‐ 1H,5H ‐pyrido[1,2‐ a ]‐benzimidazol‐1‐ones as Possible Antimicrobial and Antineoplastic Agents | Zendy

Soliman Farid S. G. | Zendy; Rida Samia M. | Zendy; Badawy ElSayed A. M. | Zendy; Kappe Thomas | Zendy

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Synthesis of Substituted 3‐Hydroxy‐ 1H,5H ‐pyrido[1,2‐ a ]‐benzimidazol‐1‐ones as Possible Antimicrobial and Antineoplastic Agents

Author(s) -

Soliman Farid S. G.,

Rida Samia M.,

Badawy ElSayed A. M.,

Kappe Thomas

Publication year - 1984

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19843171110

Subject(s) - antimicrobial , antifungal , chemistry , combinatorial chemistry , stereochemistry , in vitro , chemical synthesis , organic chemistry , microbiology and biotechnology , biochemistry , biology

Syntheses of the title compounds 3 as possible antimicrobial and antineoplastic agents were achieved by reacting the active malonates 1 with the benzimidazoles 2a,b . On the other hand, reaction of 1c,d with 2‐methylbenzimidazole (2c) yielded the imidazoquinolinones 4a,b . Four compounds in the series 3 displayed in vitro antibacterial and antifungal activities.

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