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Synthesis of Substituted 3‐Hydroxy‐ 1H,5H ‐pyrido[1,2‐ a ]‐benzimidazol‐1‐ones as Possible Antimicrobial and Antineoplastic Agents
Author(s) -
Soliman Farid S. G.,
Rida Samia M.,
Badawy ElSayed A. M.,
Kappe Thomas
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843171110
Subject(s) - antimicrobial , antifungal , chemistry , combinatorial chemistry , stereochemistry , in vitro , chemical synthesis , organic chemistry , microbiology and biotechnology , biochemistry , biology
Syntheses of the title compounds 3 as possible antimicrobial and antineoplastic agents were achieved by reacting the active malonates 1 with the benzimidazoles 2a,b . On the other hand, reaction of 1c,d with 2‐methylbenzimidazole (2c) yielded the imidazoquinolinones 4a,b . Four compounds in the series 3 displayed in vitro antibacterial and antifungal activities.