Kinetic Aspects of the Dissolution and Partition of Diclofenac, Alclofenac and Their Sodium Salts | Zendy

Zecchi Vittorio | Zendy; Rodriguez Lorenzo | Zendy; Tartarini Annarosa | Zendy; Fini Adamo | Zendy

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Kinetic Aspects of the Dissolution and Partition of Diclofenac, Alclofenac and Their Sodium Salts

Author(s) -

Zecchi Vittorio,

Rodriguez Lorenzo,

Tartarini Annarosa,

Fini Adamo

Publication year - 1984

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19843171102

Subject(s) - dissolution , chemistry , diclofenac sodium , bioavailability , sodium , diclofenac , partition coefficient , chromatography , inorganic chemistry , organic chemistry , pharmacology , biochemistry , medicine

The dissolution and the three‐phase partition profiles, vs. time, of diclofenac, alclofenac and their sodium salts have been examined in buffered mediums. The bioavailability of these drugs appears to be mainly controlled by the dissolution. The parameters influencing the higher dissolution rates of the sodium salts relative to the free acids are briefly discussed.

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