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Syntheses and Anti‐inflammatory Activities of Substituted Arylamino‐( N ′‐benzylidene)acetohydrazides and Derivatives
Author(s) -
Verma Mahima,
Gujrati Vibha R.,
Sharma Manju,
Bhalla Tirloki N.,
Saxena Anil K.,
Sinha Jagdish N.,
Bhargava Krishna P.,
Shanker Kirpa
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843171015
Subject(s) - chemistry , acute toxicity , acetic acid , lactam , ring (chemistry) , anti inflammatory , stereochemistry , medicinal chemistry , toxicity , organic chemistry , pharmacology , medicine
The substituted arylamino‐( N ′‐benzylidene)acetohydrazides 1–6 , substituted acetic acid arylamino‐( N ′‐benzyl)acetohydrazides 7–12 and N ‐(3‐chloro‐2‐oxo‐4‐phenylazetan‐1‐yl) (phenylamino)acetamides 13–16 , containing a β‐lactam ring were synthesized and studied for their anti‐inflammatory activities against carrageenin induced paw oedema in albino rats. Compound 7 was most active (30.6% at 50mg/kg p. o.) with minimum acute toxicity. All compounds showed a marked but variable (44–80%) inhibition of antiproteolytic activity.