Syntheses and Anti‐inflammatory Activities of Substituted Arylamino‐( N ′‐benzylidene)acetohydrazides and Derivatives | Zendy

Verma Mahima | Zendy; Gujrati Vibha R. | Zendy; Sharma Manju | Zendy; Bhalla Tirloki N. | Zendy; Saxena Anil K. | Zendy; Sinha Jagdish N. | Zendy; Bhargava Krishna P. | Zendy; Shanker Kirpa | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Syntheses and Anti‐inflammatory Activities of Substituted Arylamino‐( N ′‐benzylidene)acetohydrazides and Derivatives

Author(s) -

Verma Mahima,

Gujrati Vibha R.,

Sharma Manju,

Bhalla Tirloki N.,

Saxena Anil K.,

Sinha Jagdish N.,

Bhargava Krishna P.,

Shanker Kirpa

Publication year - 1984

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19843171015

Subject(s) - chemistry , acute toxicity , acetic acid , lactam , ring (chemistry) , anti inflammatory , stereochemistry , medicinal chemistry , toxicity , organic chemistry , pharmacology , medicine

The substituted arylamino‐( N ′‐benzylidene)acetohydrazides 1–6 , substituted acetic acid arylamino‐( N ′‐benzyl)acetohydrazides 7–12 and N ‐(3‐chloro‐2‐oxo‐4‐phenylazetan‐1‐yl) (phenylamino)acetamides 13–16 , containing a β‐lactam ring were synthesized and studied for their anti‐inflammatory activities against carrageenin induced paw oedema in albino rats. Compound 7 was most active (30.6% at 50mg/kg p. o.) with minimum acute toxicity. All compounds showed a marked but variable (44–80%) inhibition of antiproteolytic activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research