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Novel Phenanthridine Thiosemicarbazone and Thiazoline Derivatives: Syntheses and Evaluation for Anticancer and Antimicrobial Activities
Author(s) -
Omar A.Mohsen M. E.,
Aboulwafa Omaima M.
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843170804
Subject(s) - thiazoline , semicarbazone , phenanthridine , chemistry , antimicrobial , thio , combinatorial chemistry , stereochemistry , organic chemistry
Two novel series of thio compounds utilizing 6‐formylphenanthridine as a carrier for various thiosemicarbazone moieties, which were partly combined with variously substituted thiazoline functions, were synthesized as potential anticancer and antimicrobial agents. The thiosemicarbazones were found to be inactive against P 388 lymphocytic leukemia and the thiazolines were ineffective in the suppression of various micro‐organisms.