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Sustained Release Preparations, XVI. Collagen as a Drug Carrier
Author(s) -
Kincl Fred A.,
Ciaccio Leonard A.,
Henderson Steven B.
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843170802
Subject(s) - tetracycline , chemistry , oxytetracycline , in vitro , slurry , antibiotics , formaldehyde , drug , nuclear chemistry , tetracycline antibiotics , chromatography , biochemistry , pharmacology , materials science , composite material , medicine
Abstract Collagen‐drug complexes were prepared by dispersing acid swollen collagen (1 to 2 % on a dry weight basis) in water, adding a tetracycline antibiotic and inducing crosslinking with formaldehyde while maintaining the slurry at temperatures below 0°C. Water was mechanically removed from the spongelike network and the material was air dried. The ability of acid swollen collagen to retain tetracycline antibiotics was independent of the pH of the slurry used. Maximal release in vitro (220 mg/g of sponge) was obtained from a collagen‐oxytetracycline dihydrate system. The same preparation implanted in rabbits provided plasma levels of 2–4 μg/ml lasting more than 7 days.