Chemical Studies on Drug Metabolism II.  N ‐Demethylation and  N ‐Oxidation of Some Alicyclic Amines by Ruthenium Tetroxide | Zendy

Perrone Roberto | Zendy; Carbonara Giuseppe | Zendy; Tortorella Vincenzo | Zendy

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Chemical Studies on Drug Metabolism II. N ‐Demethylation and N ‐Oxidation of Some Alicyclic Amines by Ruthenium Tetroxide

Author(s) -

Perrone Roberto,

Carbonara Giuseppe,

Tortorella Vincenzo

Publication year - 1984

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19843170712

Subject(s) - alicyclic compound , chemistry , nonane , demethylation , lipophilicity , medicinal chemistry , organic chemistry , ruthenium , octane , steric effects , biochemistry , gene expression , dna methylation , gene , catalysis

Oxidation with ruthenium tetroxide of alicyclic N ‐methylamines such as pempidine (1a) , 9‐methyl‐9‐azabicyclo[3.3.1]nonane (2a) , and 8‐methyl‐8‐azabicyclo[3.2.1]octane (3a) , in which carbon atoms linked to nitrogen are sterically hindered, leads to the N ‐formyl and N ‐demethylated derivatives. The latter, when further oxidized, give the N ‐oxides in good yields.

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