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Piperidinediones, III. Structure‐Activity Relationships of the Enantiomers of a Series of 2,6‐Piperidinedione Derivatives
Author(s) -
Knabe Joachim,
P. Büch Horst,
Reischig Dirk
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843170708
Subject(s) - enantiomer , chemistry , anesthetic , stereochemistry , stimulation , side chain , pharmacology , anesthesia , organic chemistry , medicine , polymer
Among the racemic 2,6‐piperidinediones 1 – 6 , compound 6 has the highest anesthetic activity. The enantiomers of 1, 2, 4 and 5 possess different anesthetic potencies depending on the nature of the aliphatic side chain. The S(‐)‐enantiomers of the piperidinediones 2, 3 and 5 cause initial CNS stimulation with convulsive symptoms followed by anesthesia.