Some Reactions of 2‐Aryl‐4‐chloromethyl‐1,3,4‐thiadiazoline‐5‐thiones | Zendy

ElBarbary Ahmed A. | Zendy; Hammouda Hamdy A. | Zendy

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Some Reactions of 2‐Aryl‐4‐chloromethyl‐1,3,4‐thiadiazoline‐5‐thiones

Author(s) -

ElBarbary Ahmed A.,

Hammouda Hamdy A.

Publication year - 1984

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19843170611

Subject(s) - chemistry , thiophenol , aryl , thionyl chloride , phenols , yield (engineering) , formaldehyde , organic chemistry , alkyl , medicinal chemistry , chloride , materials science , metallurgy

Some 2‐aryl‐1,3,4‐thiadiazoline‐5‐thiones 1 react with formaldehyde to give the compounds 2 , which react with thionyl chloride to afford the compounds 3 . The latter react with phenols, thiophenol and related compounds giving 4 . With amines, 3 yield the 2‐aryl‐4‐alkyl(aryl)aminomethyl‐1,3,4‐thiadiazoline‐5‐thiones 7 . Some of the compounds described were screened bacteriologically.

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