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2,6‐Piperidinediones, I. Synthesis of the Racemates and the Enantiomers of 3,3‐Disubstituted 2,6‐Piperidinediones
Author(s) -
Knabe Joachim,
Reischig Dirk
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843170413
Subject(s) - enantiomer , chemistry , stereochemistry , optically active , bicyclic molecule , chemical synthesis , methylation , organic chemistry , in vitro , biochemistry , gene
The synthesis of the racemates and the enantiomers of the 3,3‐disubstituted 2,6‐piperidinediones 3a – 3g is performed in three ways, depending on the C‐3 substituents. The 3‐cyclohexylpiperidinedione 3h is obtained as racemic and optically active compound by hydrogenation of the cyclohexenyl compound 3e with Pd/C. The N ‐methylpiperidinediones 7a and 7b are obtained by methylation of 3a and 3b with CH 2 N 2 .