Premium
Ether Derivatives of 3‐Amino‐1,2‐propanediols, IV. Syntheses and Pharmacological Investigations of 1‐Cycloalkoxy‐3‐amino‐2‐propanols and 1‐Cycloalkoxy‐3‐guanidino‐2‐propanols
Author(s) -
Chalina Elena,
Dantchev Damian,
Georgiev Atanas,
Staneva Duschka
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843170113
Subject(s) - chemistry , guanidine , ether , ammonia , condensation , amine gas treating , organic chemistry , stereochemistry , thermodynamics , physics
By reaction of the 1‐cycloalkoxy‐2,3‐epoxypropanes 1a‐d with 25 % ammonia the 1‐cycloalkoxy‐3‐amino‐2‐propanols 2a‐d and the N,N ‐bis(3‐cycloalkoxy‐2‐hydroxypropyl)amines 3a‐d were synthesized. By condensation of 2a‐d with 2‐methyl‐2‐thiopseudourea sulfate the guanidine derivatives 4a‐c were obtained. All compounds were investigated for β‐blocking, antiarrhythmic, hypotensive and local anesthetic activities.