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Chemical Studies on Drug Metabolism: Oxidation with Ruthenium Tetroxide of Some Medicinal Alicyclic N ‐Methylamines
Author(s) -
Perrone Roberto,
Carbonara Giuseppe,
Tortorella Vincenzo
Publication year - 1984
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19843170106
Subject(s) - alicyclic compound , methylamines , chemistry , ruthenium , nicotine , organic chemistry , stereochemistry , biology , catalysis , neuroscience
Oxidation with ruthenium tetroxide of alicyclic N ‐methylamines, such as nicotine (1) , trans ‐phendi‐metrazine (2) , tropacocaine (3) and pempidine (4) , leads to the N ‐demethylated, N‐formyl and, where possible, lactam derivatives. Only from pempidine the N ‐oxide was obtained. All products obtained by this procedure are metabolites of compounds 1, 2, 3 and 4 .