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Duodenal Absorption of Oxytetracycline Hydrochloride in Rabbits Following Admixture of Cholesterol Esters
Author(s) -
Henderson Steven B.,
Ciaccio Leonard A.,
Kincl Fred A.
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833161004
Subject(s) - oxytetracycline , hydrochloride , chemistry , cholesterol , antibiotics , absorption (acoustics) , chromatography , oral administration , pharmacology , biochemistry , medicine , physics , acoustics
Cholesterol acetate admixed with oxytetracycline hydrochloride in equal proportions exhibits a maximal melting point depression. The mixture, administered orally to rabbits, provided higher and longer lasting plasma concentrations than when the same antibiotic was given with oil as the delivery vehicle.