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Synthesis of New 1‐[5‐(Substituted Phenoxymethyl)‐1,3,4‐oxadiazol‐2‐yl]‐5‐(substituted benzylidene)hydantoins as Potential Anthelminthic Agents
Author(s) -
Shukla Jagdish S.,
Agarwal Km. Kanchan
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160913
Subject(s) - chemistry , stereochemistry , hymenolepis nana , combinatorial chemistry , cestode infections , biology , helminths , zoology
Various 1‐[5‐(substituted phenoxymethyl)‐1,3,4‐oxadiazol‐2‐yl]5‐(substituted benzylidene)hydantoins have been synthesized. Their activities against Hymenolepis nana infection in rats were tested. Compound 27 was found to be the most active showing 78.0% clearance of infection at a dose of 250 mg/kg for 3 days.