Synthesis of 6‐Substituted 2‐Phenyl‐3‐(5‐substituted mercapto‐1,3,4,thiadiazol‐2‐yl)quinazolin‐4‐(3H)‐ones as Antitubercular Agents | Zendy

Kumar Piyush | Zendy; Dhawan Keshav N. | Zendy; Vrat Satya | Zendy; Bhargava Krishna P. | Zendy; Kishore Kesari | Zendy

Premium

Synthesis of 6‐Substituted 2‐Phenyl‐3‐(5‐substituted mercapto‐1,3,4,thiadiazol‐2‐yl)quinazolin‐4‐(3H)‐ones as Antitubercular Agents

Author(s) -

Kumar Piyush,

Dhawan Keshav N.,

Vrat Satya,

Bhargava Krishna P.,

Kishore Kesari

Publication year - 1983

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19833160906

Subject(s) - mycobacterium smegmatis , chemistry , mycobacterium tuberculosis , yield (engineering) , in vitro , stereochemistry , medicinal chemistry , combinatorial chemistry , tuberculosis , biochemistry , metallurgy , medicine , materials science , pathology

2‐Amino‐5‐mercapto‐1,3,4‐thiadiazole was condensed with various 6‐substituted 2‐phenylbenzoxazin‐4 (3 H )‐ones to yield the compounds 1 . When these compounds were subjected to mercaptoetherification the title compounds 2–4 were obtained. They were screened for their antitubercular activity against Mycobacterium smegmatis and Mycobacterium tuberculosis H 37 Rv in vitro. Structure‐activity relationships were established.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research