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Synthesis of 6‐Substituted 2‐Phenyl‐3‐(5‐substituted mercapto‐1,3,4,thiadiazol‐2‐yl)quinazolin‐4‐(3H)‐ones as Antitubercular Agents
Author(s) -
Kumar Piyush,
Dhawan Keshav N.,
Vrat Satya,
Bhargava Krishna P.,
Kishore Kesari
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160906
Subject(s) - mycobacterium smegmatis , chemistry , mycobacterium tuberculosis , yield (engineering) , in vitro , stereochemistry , medicinal chemistry , combinatorial chemistry , tuberculosis , biochemistry , metallurgy , medicine , materials science , pathology
2‐Amino‐5‐mercapto‐1,3,4‐thiadiazole was condensed with various 6‐substituted 2‐phenylbenzoxazin‐4 (3 H )‐ones to yield the compounds 1 . When these compounds were subjected to mercaptoetherification the title compounds 2–4 were obtained. They were screened for their antitubercular activity against Mycobacterium smegmatis and Mycobacterium tuberculosis H 37 Rv in vitro. Structure‐activity relationships were established.