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Derivatives of 2‐Amino‐1,2,3,4‐Tetrahydronaphthalene, VIII. 1 ) Isomerization of trans ‐2‐Acetamido‐3‐hydroxy‐5,8‐dimethoxy‐1,2,3,4‐tetrahydronaphthalene and Hydrolysis of 5,8‐Dimethoxy‐2‐methyl‐3 a ,4,9,9 a ‐tetrahydronaphth[2,3‐ d ]oxazoline Hydrochloride
Author(s) -
Christova Kristina,
Dantschev Damjan
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160905
Subject(s) - isomerization , chemistry , hydrolysis , hydrochloride , oxazoline , medicinal chemistry , stereochemistry , chloride , organic chemistry , catalysis
The isomerization of trans ‐2‐acetamido‐3‐hydroxy‐5,8‐dimethoxytetraline (1) under the action of hydrogen chloride was investigated. Hydrolysis of 5,8‐dimethoxy‐2‐methyl‐3 a ,4,9,9 a ‐tetrahydronaphth[2,3‐ d ]oxazoline hydrochloride (2) leads to cis ‐2‐amino‐3‐hydroxy‐5,8‐dimethoxytetraline (3) .

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