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Synthesis of Cimetidine
Author(s) -
Kairisalo Pekka,
Honkanen Erkki
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160807
Subject(s) - cimetidine , yield (engineering) , guanidine , chemistry , ethanol , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , pharmacology , medicine , materials science , metallurgy
A simple and economical synthesis of cimetidine is described. It is based on the reaction of 4‐halomethyl‐5‐methylimidazole with N ‐cyano‐ N′ ‐methyl‐ N ″‐(2‐mercaptoethyl)guanidine in water‐ethanol at pH 9.0 ± 0.3. Pure crystalline cimetidine is obtained in about 75% yield.