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Synthesis and Absolute Configurations of Hexahydro‐Naphthoxazines as Rigid Congeners of Phenmetrazine
Author(s) -
Perrone Roberto,
Bettoni Giancarlo,
Tortorella Vincenzo
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160707
Subject(s) - chemistry , stereochemistry , absolute (philosophy) , philosophy , epistemology
As part of a project concerned with the synthesis of rigid congeners of adrenergic drugs, some naphthoxazines, cis and trans isomers of 2,3,4a,5,6,10b‐hexahydro‐4 H ‐naphth[1,2‐ b ][1,4]oxazine (1) and cis and trans isomers of its isoster 2,3,4a,5,6,10b‐hexahydro‐1 H ‐naphth[2,1‐ b ][1,4]oxazine (2) were prepared. The absolute configurations of these compounds were determined by means of chemical correlation and determination of the chiroptical properties.