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Nonsteroidal Antiinflammatory Drugs, XI: 1) Thermodynamic Dissociation Constants of 3‐Substituted 3‐(4‐Biphenylyl)‐3‐hydroxypropionic Acids in Aqueous DMSO
Author(s) -
De Maria Paolo,
Fini Adamo,
Guarnieri Adriano,
Varoli Lucilla
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160615
Subject(s) - chemistry , substituent , aqueous solution , dissociation constant , nonsteroidal , solvent , acid dissociation constant , solvent effects , medicinal chemistry , organic chemistry , pharmacology , biochemistry , medicine , receptor
The thermodynamic pKa* values of 3‐substituted 3‐(4‐biphenylyl)‐3‐hydroxypropionic acids 1a‐‐s were determined potentiometrically in DMSO/water (80:20). The mixed solvent was selected for chemical and pharmacological reasons. The results are discussed in terms of substituent effects and solute‐solvent interactions. The estimated pKa values in water are in the range of 3‐‐4, in accordance with data reported in the literature for similar nonsteroidal antiinflammatory agents.