Premium
β‐Adrenoceptor Blocking Activity of 3‐Alkylamino‐1‐(3‐benzo[ b ]thienyloxy)‐2‐propanols and Closely Related Bicyclic Compounds
Author(s) -
Conde Santiago,
Corral Carlos,
Lissavetzky Jaime,
Darias Victoriano,
Galván Olga
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160612
Subject(s) - bicyclic molecule , cyclopentene , chemistry , moiety , stereochemistry , propranolol , cyclohexene , ring (chemistry) , organic chemistry , catalysis , biology , endocrinology
A preliminary pharmacological study of a thiophenic isoster of propranolol and related compounds with a tert. butylamino or homoveratrylamino group instead of the isopropylamino group is described. The synthesis and some pharmacological properties of derivatives in which the benzene ring is replaced by a cyclopentene or cyclohexene ring are also reported. Compounds carrying the tert. butylamino moiety turned out to be similar to propranolol in their pharmacological properties.