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Synthesis of Some New 2‐Substituted 3‐[4‐(N′‐Arylsulphonylbiguanido)phenyl]quinazolin‐4‐one Hydrochlorides as Potential Anthelminthic Agents
Author(s) -
Shukla Jagdish S.,
Agarwal Kanchan,
Rastogi Renu
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160610
Subject(s) - chemistry , in vivo , hymenolepis nana , quinazolinone , pharmacology , stereochemistry , cestode infections , helminths , biology , immunology , microbiology and biotechnology
The title compounds 3‐‐37 have been synthesised. Their in vivo cestodicidal activities were evaluated against Hymenolepis nana infection in rats. Compound 32 was found to be the most active of the series showing 81.0% clearance of infection at a dose of 250 mg/kg for 3 days.