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Synthesis of Some New Substituted 1,3,4‐Oxadiazoles as Potential Insecticidal, Antibacterial and Anti‐acetylcholine Esterase Agents
Author(s) -
Misra Hemant K.
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160603
Subject(s) - chemistry , esterase , antibacterial activity , acetylcholine , biological activity , stereochemistry , antibacterial agent , alkyl , organic chemistry , combinatorial chemistry , bacteria , biochemistry , enzyme , pharmacology , in vitro , antibiotics , biology , genetics
A series of 5‐substituted phenoxymethyl‐2‐[ N ‐(2‐alkyl‐1,3,4‐thiadiazol‐5‐yl)carbamoylmethylthio]‐1,3,4‐oxadiazoles have been synthesized. All compounds were tested for their insecticidal, antibacterial and anti‐acetylcholine esterase activities. Most of the compounds exhibited significant biological activity. Structure‐activity relationships have further been studied and are discussed.